A curated selection from established medical journals. Explore clinical findings, research methods, and perspectives on the future of medical research.
Selection reviewed: October 10, 2026 · Publication years shown on each article.
The BMJ · 2025Reporting guideline
CONSORT 2025: clearer reporting of clinical trials
Updated recommendations help authors explain how randomized trials were conducted and what they found. The guidance supports transparent reporting so readers can evaluate the evidence.
A reporting guideline does not establish the efficacy of a treatment.
Publication reference
CONSORT 2025 statement: updated guideline for reporting randomised trials
DOI: 10.1136/bmj-2024-081123
Read original publication ↗Nature Medicine · 2025Phase 2a randomized trial
AI-assisted drug discovery reaches a lung fibrosis trial
A 71-person, 12-week trial evaluated rentosertib, developed using generative AI, in idiopathic pulmonary fibrosis. Safety was the primary endpoint; lung-function findings supported further investigation.
Small, short-duration study; larger trials are needed to establish clinical benefit.
Publication reference
A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial
DOI: 10.1038/s41591-025-03743-2
Read original publication ↗The Lancet · 2024Pooled randomized-trial analysis
Semaglutide and obesity-related heart failure
A prespecified pooled analysis of two trials compared semaglutide with placebo in obesity-related heart failure with preserved ejection fraction. The treatment improved symptoms and physical limitations and reduced body weight in the studied population.
Findings should not be generalized to every form of heart failure.
Publication reference
STEP-HFpEF and STEP-HFpEF DM: pooled analysis
DOI: 10.1016/S0140-6736(24)00469-0
Read original publication ↗Nature Medicine · 2024Commentary
Diversity among trial participants and research leaders
This commentary addresses diversity across clinical-trial participation and leadership. It offers a perspective on representation in the research enterprise.
Commentary, rather than a randomized test of an intervention.
Publication reference
Why diversity is needed at every level of clinical trials, from participants to leaders
DOI: 10.1038/s41591-024-02914-x
Read original publication ↗NEJM · 2023Randomized clinical trial
SELECT: cardiovascular outcomes in obesity without diabetes
In people with established cardiovascular disease and overweight or obesity but without diabetes, SELECT found fewer major cardiovascular events with semaglutide than placebo. The trial examined cardiovascular outcomes in a defined high-risk population.
Results apply to the trial population; individual treatment requires medical evaluation.
Publication reference
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes
DOI: 10.1056/NEJMoa2307563
Read original publication ↗JAMA · 2019Randomized trial · Foundational study
SPRINT MIND: blood pressure and cognitive outcomes
Intensive blood-pressure control reduced mild cognitive impairment in this trial but did not significantly reduce probable dementia. The findings illustrate why primary and secondary outcomes must be interpreted separately.
Early trial termination and fewer dementia cases limited the dementia analysis.
Publication reference
Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial
DOI: 10.1001/jama.2018.21442
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Educational summaries prepared for this website. These are external publications, not studies advertised as recruiting at Integrated Health Research. They do not replace medical advice or indicate endorsement by the journals. Publisher access terms may apply to the original articles.